Correlation between invasiveness of colorectal tumor cells and adhesive potential under flow.
Anticancer Res
; 23(6C): 4891-6, 2003.
Article
in En
| MEDLINE
| ID: mdl-14981941
ABSTRACT
BACKGROUND:
Tumor cell adhesiveness is involved in metastatic dissemination, and adhesive behavior may be different under static and dynamic conditions. MATERIALS ANDMETHODS:
Patients undergoing primary colorectal cancer excision were tested for i) serum concentration of sE-selectin, sICAM-1 and sVCAM-1, ii) expression of CD18, CD29d and E-cadherin on tumor cells and iii) efficiency of tumor cell adhesion to ECV304 monolayers under flow and resistance to detachment by shear.RESULTS:
Twenty out of 31 patients were free of detectable relapse 12 months later. Relapsing and non-relapsing patients had similar levels of soluble adhesion molecules. E-cadherin was detected on tumor cells from three non-relapsing patients, but no relapsing one. Unexpectedly, significant CD18 labeling was found on two relapsing patients and one non-relapsing patient. Cells from relapsing patients displayed significantly increased (p < 0.05 two-sided, p < 0.025 one-sided) capacity to adhere to test monolayers under flow.CONCLUSION:
Cancer invasion is related to tumor cell adhesiveness, and the flow chamber provides a practical way of measuring adhesive parameters with a potential value for relapse prediction.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectal Neoplasms
/
Cell Adhesion Molecules
/
Cell Adhesion
/
Colonic Neoplasms
/
Neoplasm Invasiveness
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Anticancer Res
Year:
2003
Document type:
Article
Affiliation country: