Recombinant avian adenovirus CELO expressing the human interleukin-2: characterization in vitro, in ovo and in vivo.
Virus Res
; 100(2): 257-61, 2004 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-15019245
ABSTRACT
In our study, a recombinant adenovirus based on the avian adenovirus CELO genome, has been constructed that contains the human interleukin-2 gene. We have shown the production of biologically active recombinant interleukin-2 in vitro (LMH and 293 cells) and in ovo (chicken embryos) infected with recombinant virus CELO-IL2. An increase in the median survival time of C57BL/6 mice carrying B16 melanoma tumors has been demonstrated after multiple intra-tumors injections of the recombinant adenovirus CELO-IL2.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Melanoma, Experimental
/
Interleukin-2
/
Fowl adenovirus A
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2004
Document type:
Article
Affiliation country: