Exogenous insulin can reverse the effects of caloric restriction on mitochondria.
Biochem Biophys Res Commun
; 316(4): 1196-201, 2004 Apr 16.
Article
in En
| MEDLINE
| ID: mdl-15044112
ABSTRACT
It has been proposed that part of the anti-aging mechanism of caloric restriction (CR) involves a reduction in both the generation rate of reactive oxygen species (ROS) by mitochondria, and a reduction in peroxidizability of mitochondrial membranes. It was hypothesized that these effects may be due to upstream changes in hormonal status, since certain hormones (such as insulin) are stimulatory for ROS production, effect fatty acid composition, and are lowered by CR. To investigate this hypothesis, young male Brown-Norway rats on 55% CR (4 months duration) were subjected to insulin replacement by use of mini-osmotic pumps. ROS and free radical-induced malondialdehdye production were significantly lower in mitochondria from CR animals compared to those from fully fed, and these effects were reversed by insulin. It is concluded that the beneficial changes induced by CR, as seen at the mitochondrion, may in part be downstream effects of alterations in hormonal signalling.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitochondria, Liver
/
Signal Transduction
/
Caloric Restriction
/
Insulin
/
Malondialdehyde
/
Mitochondria, Heart
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2004
Document type:
Article
Affiliation country: