Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis.
J Neuroimmunol
; 151(1-2): 55-65, 2004 Jun.
Article
in En
| MEDLINE
| ID: mdl-15145604
ABSTRACT
Pixantrone is less cardiotoxic and is similarly effective to mitoxantrone (MTX) as an antineoplastic drug. In our study, pixantrone reduced the severity of acute and decreased the relapse rate of chronic relapsing experimental allergic encephalomyelitis (EAE) in rats. A marked and long-lasting decrease in CD3+, CD4+, CD8+ and CD45RA+ blood cells and reduced anti-MBP titers were observed with both pixantrone and MTX. In vitro mitogen- and antigen-induced T-cell proliferation tests of human and rodents cells evidenced that pixantrone was effective at concentrations which can be effectively obtained after i.v. administration in humans. Cardiotoxicity was present only in MTX-treated rats. The effectiveness and the favorable safety profile makes pixantrone a most promising immunosuppressant agent for clinical use in multiple sclerosis (MS).
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Encephalomyelitis, Autoimmune, Experimental
/
Immunosuppressive Agents
/
Isoquinolines
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
J Neuroimmunol
Year:
2004
Document type:
Article
Affiliation country: