CuI/N,N-dimethylglycine-catalyzed coupling of vinyl halides with amides or carbamates.

ABSTRACT

The CuI-catalyzed coupling reaction of vinyl halides with amides or carbamates proceeds well at room temperature to 80 degrees C in dioxane to give enamides using N,N-dimethylglycine as the promoter and Cs(2)CO(3) as the base. The geometry of the C-C double bond is retained during the reaction course. [reaction see text]