Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study.
Radiology
; 231(3): 900-5, 2004 Jun.
Article
in En
| MEDLINE
| ID: mdl-15163825
ABSTRACT
The feasibility of using sodium magnetic resonance (MR) imaging to detect proteoglycan loss in early-stage osteoarthritis is evaluated. Fixed charge density (FCD) maps were calculated from sodium MR imaging data collected in nine healthy volunteers and three individuals with symptoms of early-stage osteoarthritis by using a 4.0-T clinical MR imaging unit. Data from the healthy individuals revealed a mean FCD of -182 mmol/L +/- 9. Data from the symptomatic subjects revealed focal regions of decreased FCD, with mean values ranging from -108 to -144 mmol/L, indicating proteoglycan loss from the cartilage matrix. The data suggest that sodium MR imaging has potential for use as a quantitative diagnostic tool to measure changes in proteoglycan content in early-stage osteoarthritis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteoglycans
/
Sodium
/
Cartilage, Articular
/
Osteoarthritis, Knee
/
Knee Joint
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Radiology
Year:
2004
Document type:
Article
Affiliation country: