Magnitude of right-to-left shunt as the only determinant of stroke in a pair of identical twins.
Neurol Sci
; 25(3): 148-50, 2004 Jul.
Article
in En
| MEDLINE
| ID: mdl-15300463
ABSTRACT
Right-to-left shunt due to patent foramen ovale is a well-established risk factor for stroke in the young. The magnitude of shunt seems to be correlated to the risk of stroke in individuals. We report the cases of two 51-year-old identical twins, with similar risk factors for ischemic stroke, in which the sibling with a large and permanent shunt suffered a left hemispheric stroke and the other, with a small and latent shunt, was asymptomatic. In a three-year follow-up, the siblings were both asymptomatic, and the dimensions of shunts were unchanged. Our cases stress the importance of quantifying right-to-left shunt in order to stratify the risk of stroke in individuals, and suggest a role of heredity in patency of foramen ovale.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Twins, Monozygotic
/
Stroke
/
Heart Septal Defects, Atrial
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2004
Document type:
Article
Affiliation country: