Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin.
Glycoconj J
; 21(5): 257-66, 2004.
Article
in En
| MEDLINE
| ID: mdl-15486458
ABSTRACT
As a part of a exploring the N-glycan-mediated glycoprotein quality control in endoplasmic reticulum, 2-fluorinated derivative Glcalpha1 --> 3Man(F) 1, Glcalpha1 --> 3Man(F)alpha1 --> 2Man2, and Glcalpha1 --> 3Man(F)alpha1 --> 2Manalpha1 --> 2Man 3 were synthesized in a concise manner. These oligosaccharides were subjected to binding studies with calreticulin by using isothermal titration calorimetry. It was revealed that disaccharide 1 was a poor ligand, while tri- (2) and tetrasaccharide (3) had observable affinity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligosaccharides
/
Molecular Chaperones
/
Calnexin
/
Calreticulin
Limits:
Humans
Language:
En
Journal:
Glycoconj J
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2004
Document type:
Article