Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J Med Chem
; 47(24): 5923-36, 2004 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-15537347
ABSTRACT
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolones
/
Reverse Transcriptase Inhibitors
/
Anti-HIV Agents
/
Drug Resistance, Viral
/
HIV Reverse Transcriptase
Limits:
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2004
Document type:
Article
Affiliation country: