Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.

Li, Wenming; Pi, Rongbiao; Chan, Hugh H N; Fu, Hongjun; Lee, Nelson T K; Tsang, Hing Wai; Pu, Yongmei; Chang, Donald C; Li, Chaoying; Luo, Jialie; Xiong, Keming; Li, Zhiwang; Xue, Hong; Carlier, Paul R; Pang, Yuanping; Tsim, Karl W K; Li, Mingtao; Han, Yifan

Li, Wenming; Pi, Rongbiao; Chan, Hugh H N; Fu, Hongjun; Lee, Nelson T K; Tsang, Hing Wai; Pu, Yongmei; Chang, Donald C; Li, Chaoying; Luo, Jialie; Xiong, Keming; Li, Zhiwang; Xue, Hong; Carlier, Paul R; Pang, Yuanping; Tsim, Karl W K; Li, Mingtao; Han, Yifan.

Affiliation

Li W; Department of Biochemistry and Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong.

J Biol Chem ; 280(18): 18179-88, 2005 May 06.

Article in En | MEDLINE | ID: mdl-15710623

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Tacrine / Cholinesterase Inhibitors / Apoptosis / Receptors, N-Methyl-D-Aspartate / Glutamic Acid / Indans / Neurons Limits: Animals Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: Country of publication:

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