Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

Hoet, René Michael; Cohen, Edward H; Kent, Rachel Baribault; Rookey, Kristin; Schoonbroodt, Sonia; Hogan, Shannon; Rem, Louise; Frans, Nicolas; Daukandt, Marc; Pieters, Henk; van Hegelsom, Rob; Neer, Nicole Coolen-van; Nastri, Horacio G; Rondon, Isaac J; Leeds, Jennifer A; Hufton, Simon E; Huang, Lili; Kashin, Irina; Devlin, Mary; Kuang, Guannan; Steukers, Mieke; Viswanathan, Malini; Nixon, Andrew E; Sexton, Daniel J; Hoogenboom, Hennie R; Ladner, Robert Charles

Hoet, René Michael; Cohen, Edward H; Kent, Rachel Baribault; Rookey, Kristin; Schoonbroodt, Sonia; Hogan, Shannon; Rem, Louise; Frans, Nicolas; Daukandt, Marc; Pieters, Henk; van Hegelsom, Rob; Neer, Nicole Coolen-van; Nastri, Horacio G; Rondon, Isaac J; Leeds, Jennifer A; Hufton, Simon E; Huang, Lili; Kashin, Irina; Devlin, Mary; Kuang, Guannan; Steukers, Mieke; Viswanathan, Malini; Nixon, Andrew E; Sexton, Daniel J; Hoogenboom, Hennie R; Ladner, Robert Charles.

Nat Biotechnol ; 23(3): 344-8, 2005 Mar.

Article in En | MEDLINE | ID: mdl-15723048

Subject(s)

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Protein Engineering / Peptide Library / Complementarity Determining Regions / Antibody Affinity / Antibody Formation Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2005 Document type: Article

Search on Google

Add to My VHL

XML

PubMed Links