In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft model.
Cancer Chemother Pharmacol
; 56(1): 70-4, 2005 Jul.
Article
in En
| MEDLINE
| ID: mdl-15806415
ABSTRACT
Previously we have shown that 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42+/-0.11 g and 0.59+/-0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60+/-0.80% of the total in mice injected with 150 mg/kg DMC). To our knowledge, this is the first time that chalcone compounds have been applied to a human tumor xenograft model.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Carcinoma
/
Chalcone
/
Myrtaceae
/
Liver Neoplasms
Limits:
Animals
Language:
En
Journal:
Cancer Chemother Pharmacol
Year:
2005
Document type:
Article