Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia.
Prog Neuropsychopharmacol Biol Psychiatry
; 29(4): 603-10, 2005 May.
Article
in En
| MEDLINE
| ID: mdl-15866364
ABSTRACT
Diagnosis of dementia of the Alzheimer's type depends on clinical criteria and exclusion of other disorders because, at this time, a validated biological marker, aside from histological brain examination, remains to be established. The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD). In order to investigate the first events taking place in canine cognitive dysfunction, in this paper we established a new and rapid behavioral test that finely discriminates the degrees of cognitive impairment. Cerebrospinal fluid (CSF) analysis was performed to determine the relationship between each disease stage and modification of cerebral energy metabolism. Our results demonstrate a parallel increase of lactate, pyruvate and potassium concentrations in the severe cognitive deficit. These differences are discussed in view of the neuroprotective role presently given to lactate.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognition Disorders
/
Lactic Acid
/
Pyruvic Acid
/
Alzheimer Disease
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Prog Neuropsychopharmacol Biol Psychiatry
Year:
2005
Document type:
Article
Affiliation country: