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In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections.
Giacometti, Andrea; Cirioni, Oscar; Kamysz, Wojciech; Silvestri, Carmela; Del Prete, Maria Simona; Licci, Alberto; D'Amato, Giuseppina; Lukasiak, Jerzy; Scalise, Giorgio.
Affiliation
  • Giacometti A; Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
Antimicrob Agents Chemother ; 49(6): 2507-9, 2005 Jun.
Article in En | MEDLINE | ID: mdl-15917557
ABSTRACT
The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gram-Positive Cocci / Skin Diseases, Bacterial / Soft Tissue Infections / Antimicrobial Cationic Peptides / Amphibian Proteins / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2005 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gram-Positive Cocci / Skin Diseases, Bacterial / Soft Tissue Infections / Antimicrobial Cationic Peptides / Amphibian Proteins / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2005 Document type: Article Affiliation country: