LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro.
Ann N Y Acad Sci
; 1041: 22-6, 2005 May.
Article
in En
| MEDLINE
| ID: mdl-15956683
ABSTRACT
The relaxin receptor (LGR7) and the insulin-like peptide 3 (INSL3) receptor (LGR8) are unique LGR family members in possessing a single, functionally important amino terminal LDL-A module.1 Mouse and rat cDNA was screened for LGR7 and LGR7 splice variant expression. A uterus-specific exon 4 deleted variant was identified and named LGR7-Truncate. Deletion of exon 4 results in a premature stop codon and a transcript that putatively encodes a secreted protein containing LGR7's LDL-A module. Expression of LGR7-Truncate with LGR7 in HEK-293T cells resulted in decreased relaxin-induced signaling of LGR7. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Relaxin
/
Alternative Splicing
/
Receptors, Peptide
/
Receptors, G-Protein-Coupled
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Ann N Y Acad Sci
Year:
2005
Document type:
Article
Affiliation country: