Correlation between detection of antibodies against hepatitis C virus in oral fluid and hepatitis C virus RNA in serum.
Eur J Clin Microbiol Infect Dis
; 24(8): 566-8, 2005 Aug.
Article
in En
| MEDLINE
| ID: mdl-16133413
ABSTRACT
Reported here are the results of a study designed to determine the correlation between hepatitis C virus (HCV) RNA positivity in serum and the detection of antibodies against HCV in oral fluid by testing paired serum/oral fluid samples. For the 85 serum samples found positive for antibodies against HCV, using a screening assay and a confirmation assay, 70 of the corresponding oral fluid samples tested positive for HCV antibodies using a previously modified screening assay. For 52 of the 59 serum samples found positive for HCV RNA, the corresponding oral fluid samples also tested seropositive for HCV, while 18 of the 26 serum samples that were negative for HCV RNA had corresponding oral fluid samples that tested seropositive for HCV. For the control group of 54 serum samples that were negative for HCV antibodies, all of the corresponding oral fluid samples were also negative for HCV antibodies, while 53 of the serum samples tested negative for HCV RNA. These results suggest that HCV antibody detection in oral fluid has a slightly higher sensitivity when used to test patients whose serum samples are positive for HCV RNA (chi-square test, p=0.035; Mid-P exact, p=0.049).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saliva
/
RNA, Viral
/
Hepatitis C
/
Hepacivirus
/
Hepatitis C Antibodies
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Eur J Clin Microbiol Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2005
Document type:
Article
Affiliation country: