Autologous fibrin glue in peripheral nerve regeneration in vivo.
Microsurgery
; 25(6): 495-9, 2005.
Article
in En
| MEDLINE
| ID: mdl-16145682
ABSTRACT
The activity of several growth factors on peripheral nerve regeneration is reported. Autologous fibrin glue contains a large number of platelets, which release significant quantities of growth factors. In order to understand the role of autologous fibrin glue in peripheral nerve regeneration, a 15-mm rabbit peroneal nerve defect was repaired using a vein graft filled with autologous fibrin glue. Axonal regeneration was examined using histological and electrophysiological methods. The extent of axonal regeneration was superior when treated with autologous fibrin glue. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in autologous fibrin glue, might effectively promote peripheral nerve regeneration in nerve defects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peroneal Nerve
/
Tissue Adhesives
/
Fibrin Tissue Adhesive
/
Peroneal Neuropathies
/
Jugular Veins
/
Nerve Regeneration
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Microsurgery
Year:
2005
Document type:
Article
Affiliation country: