Chemical synthesis of the novel Ca2+ messenger NAADP.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 513-8, 2005.
Article
in En
| MEDLINE
| ID: mdl-16247981
ABSTRACT
The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (beta-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine dinucleotide phosphate (p-NAADP) 1 and the identity of this material confirmed by biological evaluation. This flexible synthetic route offers new opportunities for the generation of NAADP 1 analogues that cannot be generated directly from NADP 2 or mainly enzymatic methods.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Calcium
/
NADP
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Nucleosides Nucleotides Nucleic Acids
Journal subject:
BIOQUIMICA
Year:
2005
Document type:
Article
Affiliation country: