Structure of a V3-containing HIV-1 gp120 core.
Science
; 310(5750): 1025-8, 2005 Nov 11.
Article
in En
| MEDLINE
| ID: mdl-16284180
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
CD4 Antigens
/
HIV Envelope Protein gp120
/
HIV-1
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Science
Year:
2005
Document type:
Article
Affiliation country:
Country of publication: