[Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma].
Hua Xi Kou Qiang Yi Xue Za Zhi
; 23(5): 431-3, 2005 Oct.
Article
in Zh
| MEDLINE
| ID: mdl-16285555
ABSTRACT
OBJECTIVE:
To detective the relationship between cyclooxygenase-2 (COX-2) and angiogenesis in oral squamous cell carcinoma (OSCC) and its clinical significance through observing the expression of COX-2 and determining microvessel density (MVD) in OSCC.METHODS:
PV-9000 immunohistochemistry was used to determine the expression of COX-2 and CD34, which was used to determine MVD, in 76 OSCC tissues and 12 normal oral mucosa tissues.RESULTS:
Overexpression of COX-2 was detected in OSCC, and was more intense compared with normal epithelium (P < 0.001). The high expression of COX-2 in OSCC was related to neck lymphnode metastasis, tumor size, TNM stage and histological grade (P <0.05). The MVD value in COX-2-positive group was much higher than that in COX-2-negative group (P < 0.01) and that in normal oral mucosa tissues (P < 0.01).CONCLUSION:
The high expression of COX-2 in OSCC was significantly associated with MVD, neck lymphnode metastasis, tumor size, TNM stage and histological grade. COX-2 might be one of the important factors in the angiogenesis of OSCC.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Cyclooxygenase 2
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Hua Xi Kou Qiang Yi Xue Za Zhi
Journal subject:
ODONTOLOGIA
Year:
2005
Document type:
Article
Affiliation country: