Fatigue in long-term breast carcinoma survivors: a longitudinal investigation.
Cancer
; 106(4): 751-8, 2006 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-16400678
ABSTRACT
BACKGROUND:
A longitudinal study was designed to evaluate the prevalence, persistence, and predictors of posttreatment fatigue in breast carcinoma survivors.METHODS:
A sample of 763 breast carcinoma survivors completed questionnaires at 1-5 and 5-10 years after diagnosis, including the RAND 36-item Health Survey, Center for Epidemiological Studies - Depression scale (CES-D), Breast Cancer Prevention Trial Symptom Checklist, and demographic and treatment-related measures.RESULTS:
Approximately 34% of study participants reported significant fatigue at 5-10 years after diagnosis, which is consistent with prevalence estimates obtained at 1-5 years after diagnosis. Approximately 21% reported fatigue at both assessment points, indicating a more persistent symptom profile. Longitudinal predictors of fatigue included depression, cardiovascular problems, and type of treatment received. Women treated with either radiation or chemotherapy alone showed a small improvement in fatigue compared with those treated with both radiation and chemotherapy.CONCLUSIONS:
Fatigue continues to be a problem for breast carcinoma survivors many years after cancer diagnosis, with 21% reporting persistent problems with fatigue. Several factors that may contribute to long-term fatigue are amenable to intervention, including depression and comorbid medical conditions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Fatigue
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Cancer
Year:
2006
Document type:
Article
Affiliation country: