Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas.
Cancer Biol Ther
; 5(7): 827-32, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16760646
ABSTRACT
Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern. Microvessel density (MVD) has been correlated to clinical outcome in astrocytomas, but its impact in oligodendrogliomas and mixed tumors is not sure. The pro-angiogenic chemokine stromal cell-derived factor (SDF-1/CXCL12) and its receptor CXC chemokine receptor 4 (CXCR4) have been described in low-grade gliomas, with a correlation between CXCL12 expression and shorter time to progression (TTP). The intermediate filament Nestin is expressed in proliferating vessels. Platelet-derived growth factor B (PDGF-B) and its receptor PDGFR-beta are also involved in angiogenesis and malignant progression in gliomas.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligodendroglioma
/
Astrocytoma
/
Brain Neoplasms
/
Chemokines, CXC
/
Neovascularization, Pathologic
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cancer Biol Ther
Journal subject:
NEOPLASIAS
/
TERAPEUTICA
Year:
2006
Document type:
Article
Affiliation country: