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IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.
Sosa, Lucas; Dupraz, Sebastian; Laurino, Lisandro; Bollati, Flavia; Bisbal, Mariano; Cáceres, Alfredo; Pfenninger, Karl H; Quiroga, Santiago.
Affiliation
  • Sosa L; Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba y Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Consejo de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
Nat Neurosci ; 9(8): 993-5, 2006 Aug.
Article in En | MEDLINE | ID: mdl-16845384
ABSTRACT
How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.
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Collection: 01-internacional Database: MEDLINE Main subject: Cell Polarity / Receptor, IGF Type 1 / Hippocampus / Neurons Limits: Animals Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2006 Document type: Article Affiliation country:
Search on Google
Add to My VHL
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Cell Polarity / Receptor, IGF Type 1 / Hippocampus / Neurons Limits: Animals Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2006 Document type: Article Affiliation country: