Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives.
J Med Chem
; 49(15): 4790-4, 2006 Jul 27.
Article
in En
| MEDLINE
| ID: mdl-16854087
ABSTRACT
A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in vitro. Strong activity against HBV replication and low cytotoxicity were generally observed in these benzimidazoles. The most promising compounds were 12a and 12b, with similar high antiviral potency (IC50 = 0.9 and 0.7 microM, respectively) and remarkable selectivity indices (>1111 and 714, respectively). They were selected for further evaluation as novel HBV inhibitors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Benzimidazoles
/
Hepatitis B virus
Limits:
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2006
Document type:
Article
Affiliation country: