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Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives.
Li, Yun-Fei; Wang, Gui-Feng; He, Pei-Lan; Huang, Wei-Gang; Zhu, Feng-Hua; Gao, He-Yong; Tang, Wei; Luo, Yu; Feng, Chun-Lan; Shi, Li-Ping; Ren, Yu-Dan; Lu, Wei; Zuo, Jian-Ping.
Affiliation
  • Li YF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
J Med Chem ; 49(15): 4790-4, 2006 Jul 27.
Article in En | MEDLINE | ID: mdl-16854087
ABSTRACT
A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in vitro. Strong activity against HBV replication and low cytotoxicity were generally observed in these benzimidazoles. The most promising compounds were 12a and 12b, with similar high antiviral potency (IC50 = 0.9 and 0.7 microM, respectively) and remarkable selectivity indices (>1111 and 714, respectively). They were selected for further evaluation as novel HBV inhibitors.
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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Benzimidazoles / Hepatitis B virus Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country:
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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Benzimidazoles / Hepatitis B virus Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: