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Adherence of Staphylococcus epidermidis to biomaterials is augmented by PIA.
Olson, M E; Garvin, K L; Fey, P D; Rupp, M E.
Affiliation
  • Olson ME; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Clin Orthop Relat Res ; 451: 21-4, 2006 Oct.
Article in En | MEDLINE | ID: mdl-16906069
ABSTRACT
Staphylococcus epidermidis is the most common cause of orthopaedic prosthetic device infections. Polysaccharide intercellular adhesin (PIA) is important in the pathogenesis of intravascular catheter-associated infection, and has an essential role in cellular aggregation and biofilm formation. However, the role of PIA in orthopaedic infections is less well understood. We used genetically defined strains of S. epidermidis in an in vitro adherence assay to assess the importance of PIA in the adherence to various orthopaedic biomaterials. On all biomaterials tested (zirconia, ultra-high molecular weight polyethylene, polymethylmethacrylate, cobalt chromium, titanium, stainless steel, and silastic), PIA-positive S. epidermidis 1457 exhibited greater levels of adherence thanS. epidermidis 1457 M10, an isogenic icaA Tn917 mutant. PIA appears to play a critical role in the adherence of S. epidermidis to orthopaedic biomaterials, and may serve as an important virulence determinant in orthopaedic prosthetic device infections.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides, Bacterial / Staphylococcus epidermidis / Biocompatible Materials / Bacterial Adhesion Language: En Journal: Clin Orthop Relat Res Year: 2006 Document type: Article Affiliation country:
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides, Bacterial / Staphylococcus epidermidis / Biocompatible Materials / Bacterial Adhesion Language: En Journal: Clin Orthop Relat Res Year: 2006 Document type: Article Affiliation country: