Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.
Genes Dev
; 20(21): 2937-42, 2006 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-17050674
ABSTRACT
The perichondrium, a structure made of undifferentiated mesenchymal cells surrounding growth plate cartilage, regulates chondrocyte maturation through poorly understood mechanisms. Analyses of loss- and gain-of-function models show that Twist-1, whose expression in cartilage is restricted to perichondrium, favors chondrocyte maturation in a Runx2-dependent manner. Runx2, in turn, enhances perichondrial expression of Fgf18, a regulator of chondrocyte maturation. Accordingly, compound heterozygous embryos for Runx2 and Fgf18 deletion display the same chondrocyte maturation phenotype as Fgf18-null embryos. This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Developmental
/
Chondrogenesis
/
Core Binding Factor Alpha 1 Subunit
/
Fibroblast Growth Factors
/
Mesoderm
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
2006
Document type:
Article
Affiliation country: