Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report.
J Transl Med
; 4: 43, 2006 Oct 24.
Article
in En
| MEDLINE
| ID: mdl-17062151
ABSTRACT
BACKGROUND:
Although described by Hippocrates in 400 B.C., pemphigus disease still needs a safe therapeutical approach, given that the currently used therapies (i.e. corticosteroids and immunosuppressive drugs) often provoke collateral effects. Here we present preliminary data on the possible use of a proteomics derived desmoglein peptide which appears promising in halting disease progression without adverse effects.METHODS:
The low-similarity Dsg349-60REWVKFAKPCRE peptide was topically applied for 1 wk onto a lesion in a patient with a late-stage Pemphigus vulgaris (PV) complicated by diabetes and cataract disease. The peptide was applied as an adjuvant in combination with the standard corticosteroid-based immunosuppressive treatment.RESULTS:
After 1 wk, the treated PV eroded lesion appeared dimensionally reduced and with an increased rate of re-epithelization when compared to adjacent non-treated lesions. Short-term benefits were decrease of anti-Dsg antibody titer and reduction of the corticosteroid dosage. Long-term benefits after two years following the unique 1-wk topical treatment, the decrease of anti-Dsg antibody titer persists. The patient is still at the low cortisone dosage. Adverse effects no adverse effect could be monitored.CONCLUSION:
With the limits inherent to any preliminary study, this case report indicates that topical treatment with Dsg349-60REWVKFAKPCRE peptide may represent a feasible first step in the search for a simple, effective and safe treatment of PV.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Transl Med
Year:
2006
Document type:
Article
Affiliation country: