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Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Slater, Martin J; Amphlett, Elizabeth M; Andrews, David M; Bravi, Gianpaolo; Burton, George; Cheasty, Anne G; Corfield, John A; Ellis, Malcolm R; Fenwick, Rebecca H; Fernandes, Stephanie; Guidetti, Rossella; Haigh, David; Hartley, C David; Howes, Peter D; Jackson, Deborah L; Jarvest, Richard L; Lovegrove, Victoria L H; Medhurst, Katrina J; Parry, Nigel R; Price, Helen; Shah, Pritom; Singh, Onkar M P; Stocker, Richard; Thommes, Pia; Wilkinson, Claire; Wonacott, Alan.
Affiliation
  • Slater MJ; Infectious Diseases CEDD and Medicinal Discovery Research, GlaxoSmithKline, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom. martin.j.slater@gsk.com
J Med Chem ; 50(5): 897-900, 2007 Mar 08.
Article in En | MEDLINE | ID: mdl-17269759
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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrrolidines / RNA-Dependent RNA Polymerase / Hepacivirus Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrrolidines / RNA-Dependent RNA Polymerase / Hepacivirus Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: Country of publication: