Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.
Bioorg Med Chem Lett
; 17(7): 1930-3, 2007 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-17270443
ABSTRACT
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pyrrolidines
/
Replicon
/
RNA-Dependent RNA Polymerase
/
Chemistry, Pharmaceutical
/
Viral Nonstructural Proteins
/
Hepacivirus
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
