Role of monoclonal antibodies in tumor-specific immunity.
Expert Opin Biol Ther
; 7(3): 331-43, 2007 Mar.
Article
in En
| MEDLINE
| ID: mdl-17309325
ABSTRACT
Monoclonal antibodies, considered to be 'magic bullets' 20 years ago, may finally be realizing their full potential, particularly in the area of oncology, where > 10 monoclonal antibodies are approved for treatment. Monoclonal antibodies are being used to modulate tumor-specific immunity through several approaches antibodies that direct cytotoxicity against the tumor through cellular or complement-mediated pathways; antibodies that directly modulate immune regulation; antibodies that alter tolerance to tumor antigens; and antibodies that act as antigen mimetics through the anti-idiotype network. Therapeutic progress in these areas is reviewed as well as the potential to combine these approaches with standard therapies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies, Monoclonal
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Expert Opin Biol Ther
Journal subject:
BIOLOGIA
/
TERAPEUTICA
Year:
2007
Document type:
Article
Affiliation country: