Drug Design; Matrix Metalloproteinase Inhibitors; Protease Inhibitors/pharmacology; Animals; Arthritis/drug therapy; Arthritis/enzymology; Atherosclerosis/drug therapy; Atherosclerosis/enzymology; Extracellular Matrix Proteins/metabolism; Eye Diseases/drug therapy; Eye Diseases/enzymology; Heart Rupture, Post-Infarction/drug therapy; Heart Rupture, Post-Infarction/enzymology; Humans; Hypertrophy, Left Ventricular/drug therapy; Hypertrophy, Left Ventricular/enzymology; Matrix Metalloproteinases/metabolism; Myocardial Infarction/drug therapy; Myocardial Infarction/enzymology; Neoplasms/drug therapy; Neoplasms/enzymology; Protease Inhibitors/therapeutic use; Pulmonary Disease, Chronic Obstructive/drug therapy; Pulmonary Disease, Chronic Obstructive/enzymology; Respiratory Distress Syndrome/drug therapy; Respiratory Distress Syndrome/enzymology; Skin Diseases/drug therapy; Skin Diseases/enzymology; Stroke/drug therapy; Stroke/enzymology; Vascular Diseases/drug therapy; Vascular Diseases/enzymology