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Crossing paths with Notch in the hyper-network.
Hurlbut, Gregory D; Kankel, Mark W; Lake, Robert J; Artavanis-Tsakonas, Spyros.
Affiliation
  • Hurlbut GD; Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA.
Curr Opin Cell Biol ; 19(2): 166-75, 2007 Apr.
Article in En | MEDLINE | ID: mdl-17317139
The development of complex and diverse metazoan morphologies is coordinated by a surprisingly small number of evolutionarily conserved signaling mechanisms. These signals can act in parallel but often appear to function as an integrated hyper-network. The nodes defining this complex molecular circuitry are poorly understood, but the biological significance of pathway cross-talk is profound. The importance of such large-scale signal integration is exemplified by Notch and its ability to cross-talk with all the major pathways to influence cell differentiation, proliferation, survival and migration. The Notch pathway is, thus, a useful paradigm to illustrate the complexity of pathway cross-talk: its pervasiveness, context dependency, and importance in development and disease.
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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptor Cross-Talk / Receptors, Notch Limits: Animals / Humans Language: En Journal: Curr Opin Cell Biol Year: 2007 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptor Cross-Talk / Receptors, Notch Limits: Animals / Humans Language: En Journal: Curr Opin Cell Biol Year: 2007 Document type: Article Affiliation country: Country of publication: