Crossing paths with Notch in the hyper-network.
Curr Opin Cell Biol
; 19(2): 166-75, 2007 Apr.
Article
in En
| MEDLINE
| ID: mdl-17317139
The development of complex and diverse metazoan morphologies is coordinated by a surprisingly small number of evolutionarily conserved signaling mechanisms. These signals can act in parallel but often appear to function as an integrated hyper-network. The nodes defining this complex molecular circuitry are poorly understood, but the biological significance of pathway cross-talk is profound. The importance of such large-scale signal integration is exemplified by Notch and its ability to cross-talk with all the major pathways to influence cell differentiation, proliferation, survival and migration. The Notch pathway is, thus, a useful paradigm to illustrate the complexity of pathway cross-talk: its pervasiveness, context dependency, and importance in development and disease.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Receptor Cross-Talk
/
Receptors, Notch
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2007
Document type:
Article
Affiliation country:
Country of publication: