Improved plasmalogen synthesis using organobarium intermediates.
J Org Chem
; 72(13): 5005-7, 2007 Jun 22.
Article
in En
| MEDLINE
| ID: mdl-17539687
ABSTRACT
An improved synthesis of plasmalogen type lipids is described. Transmetalation of lithioalkoxy allyl intermediates with BaI(2) and subsequent alkylation with 1-iodoalkanes enables the stereoselective formation of O-(Z)-alkenyl ether as precursors for the synthesis of plasmenyl- and bisplasmenylcholines. This method provides a simple and adaptable approach for the stereocontrolled synthesis of plasmenyl derivatives with variations at the sn-1, sn-2, and sn-3 positions of the glycerol backbone.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organic Chemicals
/
Plasmalogens
/
Barium Compounds
Language:
En
Journal:
J Org Chem
Year:
2007
Document type:
Article
Affiliation country: