Cross-talk between the NR3B and NR4A families of orphan nuclear receptors.
Biochem Biophys Res Commun
; 359(2): 391-7, 2007 Jul 27.
Article
in En
| MEDLINE
| ID: mdl-17543277
ABSTRACT
Estrogen-related receptors (NR3B family) and Nurr1, NGFI-B, and Nor1 (NR4A family) are orphan nuclear receptors lacking identified natural ligands. The mechanisms regulating their transcriptional activities have remained elusive. We have previously observed that the members of NR3B and NR4A families are coexpressed in certain cell types such as osteoblasts and that the ability of Nurr1 to transactivate the osteopontin promoter is repressed by ERRs. We have now studied the cross-talk between NR3B and NR4A receptors. We show that NR3B and NR4A receptors mutually repress each others' transcriptional activity. The repression involves intact DNA-binding domains and dimerization interfaces but does not result from competition for DNA binding or from heterodimerization. The activation functions of NR3B and NR4A receptors are dispensable for the cross-talk. In conclusion, we report that cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Receptors, Steroid
/
Cell Nucleus
/
Receptors, N-Methyl-D-Aspartate
/
Receptors, Cytoplasmic and Nuclear
/
DNA-Binding Proteins
/
Estrogens
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2007
Document type:
Article
Affiliation country: