Severe immediate reaction to nabumetone.
J Investig Allergol Clin Immunol
; 17(4): 274-6, 2007.
Article
in En
| MEDLINE
| ID: mdl-17694703
ABSTRACT
Nabumetone is a nonsteroidal antiinflammatory (NSAID) prodrug that inhibits cyclooxygenase-2. It has been recommended as a safe alternative in most patients with hypersensitivity reactions to NSAIDs. Systemic reactions caused by nabumetone are not frequent. We report 2 cases of immediate systemic reactions due to nabumetone. The first case involved a 68-year-old woman who developed immediate generalized pruritus, erythema, morbilliform eruption, swollen tongue sensation, diarrhea, and hypotension after the ingestion of a single dose of nabumetone. In the second case, a 77-year-old woman developed generalized pruritus, palm erythema, colic abdominal pain, diarrhea, dizziness, tightness of the chest, dyspnea, and hypotension immediately after oral intake of nabumetone. Both patients had previously tolerated this drug. Since these episodes, they have avoided nabumetone. Skin prick tests with nabumetone (10 and 100 mg/mL) were negative. Oral challenge tests with other NSAIDs, even of the same group as nabumetone, were negative in both patients. The mechanisms responsible for the reaction were not established.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Butanones
/
Anti-Inflammatory Agents, Non-Steroidal
/
Drug Hypersensitivity
Type of study:
Diagnostic_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
J Investig Allergol Clin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2007
Document type:
Article
Affiliation country: