Successful treatment of a giant isolated cerebral mucormycotic (zygomycotic) abscess using endoscopic debridement: case report and therapeutic considerations.
Surg Neurol
; 69(5): 510-5; discussion 515, 2008 May.
Article
in En
| MEDLINE
| ID: mdl-17707491
ABSTRACT
BACKGROUND:
Cerebral mucormycosis without rhino-orbital or systemic involvement is an extremely rare condition mostly associated with parenteral drug abuse. CASE DESCRIPTION We report the case of a 42-year-old woman who presented with hemiparesis of the left side and altered mental status. Neuroradiologic workup demonstrated an inflammatory lesion involving the right basal ganglia. Proton magnetic resonance spectroscopy demonstrated features consistent with a pyogenic abscess. Computed tomography-guided stereotactic biopsy led to the diagnosis of cerebral mucormycosis. Parenteral AMB-L treatment was conducted, but the patient worsened clinically, presenting with a complete hemiplegia, and cerebral magnetic resonance imaging (MRI) scans demonstrated a voluminous abscess formation. Then, under stereotactic guidance, a surgical endoscopic debridement of the abscess cavity associated with the placement of an Ommaya reservoir was performed. Systemic and intralesional treatment with AmB associated with an adjunctive immune therapy was conducted. At 3-year follow-up, the patient had recovered partially from her left hemiplegia, allowing her to walk without help, and cerebral MRI scans showed complete resorption of the abscess.CONCLUSION:
Our good results suggest that surgical endoscopic debridement associated with intravenous and intracavitary antifungal therapy might be valuable in treating voluminous deep-seated mucormycotic lesions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Abscess
/
Central Nervous System Fungal Infections
/
Debridement
/
Endoscopy
/
Mucormycosis
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Surg Neurol
Year:
2008
Document type:
Article
Affiliation country: