Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus.
Vaccine
; 25(43): 7481-90, 2007 Oct 23.
Article
in En
| MEDLINE
| ID: mdl-17905485
ABSTRACT
A Semliki Forest virus (SFV) recombinant particle vaccine vector was constructed expressing the viral E1 and E2 envelope proteins of the RA27/3 vaccine strain of rubella virus. This vector induced high titres of antibody after intramuscular administration to Balb/C mice, both following initial vaccination and a boost 4 weeks later. This occurred for antibody as measured by ELISA and as measured by a latex agglutination test. However, co-administration of similar particles expressing the measles virus H protein and the mumps virus HN protein with the rubella protein expressing vector resulted in reduction of the anti-rubella immune response.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rubella virus
/
Viral Envelope Proteins
/
Genetic Vectors
/
Measles virus
/
Mumps virus
/
Antigens, Viral
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2007
Document type:
Article
Affiliation country: