Design and synthesis of alpha-helical peptides and mimetics.
Org Biomol Chem
; 5(22): 3577-85, 2007 Nov 21.
Article
in En
| MEDLINE
| ID: mdl-17971985
ABSTRACT
The alpha-helix is the most abundant secondary structural element in proteins and is an important structural domain for mediating protein-protein and protein-nucleic acid interactions. Strategies for the rational design and synthesis of alpha-helix mimetics have not matured as well as other secondary structure mimetics such as strands and turns. This perspective will focus on developments in the design, synthesis and applications of alpha-helices and mimetics, particularly in the last 5 years. Examples where synthetic compounds have delivered promising biological results will be highlighted as well as opportunities for the design of mimetics of the type I alpha-helical antifreeze proteins.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Drug Design
/
Biomimetic Materials
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country: