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Transforming growth factor-beta receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?
Sharifi, Nima; Lechleider, Robert J; Farrar, William L.
Affiliation
  • Sharifi N; Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, Frederick, Maryland 21702, USA. nima.sharifi@nih.gov
J Mol Endocrinol ; 39(5): 329-32, 2007 Nov.
Article in En | MEDLINE | ID: mdl-17975259
ABSTRACT
The transforming growth factor-beta (TGF-beta) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-beta receptor III is the most common TGF-beta pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.
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Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Proteoglycans / Down-Regulation / Receptors, Transforming Growth Factor beta / Tumor Suppressor Proteins / Inhibins Limits: Humans / Male Language: En Journal: J Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2007 Document type: Article Affiliation country:
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Proteoglycans / Down-Regulation / Receptors, Transforming Growth Factor beta / Tumor Suppressor Proteins / Inhibins Limits: Humans / Male Language: En Journal: J Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2007 Document type: Article Affiliation country: