Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series.

Ceccarelli, Simona M; Schlotterbeck, Götz; Boissin, Patrick; Binder, Martin; Buettelmann, Bernd; Hanlon, Steven; Jaeschke, Georg; Kolczewski, Sabine; Kupfer, Ernst; Peters, Jens-Uwe; Porter, Richard H P; Prinssen, Eric P; Rueher, Marianne; Ruf, Iris; Spooren, Will; Stämpfli, Andreas; Vieira, Eric

Ceccarelli, Simona M; Schlotterbeck, Götz; Boissin, Patrick; Binder, Martin; Buettelmann, Bernd; Hanlon, Steven; Jaeschke, Georg; Kolczewski, Sabine; Kupfer, Ernst; Peters, Jens-Uwe; Porter, Richard H P; Prinssen, Eric P; Rueher, Marianne; Ruf, Iris; Spooren, Will; Stämpfli, Andreas; Vieira, Eric.

Affiliation

Ceccarelli SM; Pharmaceuticals Division, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland. simona_m.ceccarelli@roche.com

ChemMedChem ; 3(1): 136-44, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17994660

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Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Microsomes, Liver / Pharmaceutical Preparations / Receptors, Metabotropic Glutamate / Aminopyridines Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication:

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