Gabapentin for decerebrate rigidity: a case report.
Clin Drug Investig
; 28(1): 67-70, 2008.
Article
in En
| MEDLINE
| ID: mdl-18081362
ABSTRACT
A 48-year-old woman suddenly lost consciousness as a result of a right rostral pontine tegmentum haemorrhage. The patient presented with decerebrate rigidity (DR) and regained full consciousness 5 days after the initial onset. The patient was given gabapentin 1200 mg/day nasogastrically and her DR significantly improved, although other antiepileptic drugs such as phenytoin and carbamazepine were given in larger dosages to decrease muscle hypertonicity. The patients' preserved consciousness and motor-evoked potentials to transcranial magnetic stimulation indicated a derangement of the extrapyramidal tracts with preservation of the pyramidal tracts. This case report discusses the possible mechanisms of action of gabapentin in DR.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyclohexanecarboxylic Acids
/
Decerebrate State
/
Gamma-Aminobutyric Acid
/
Amines
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Clin Drug Investig
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2008
Document type:
Article
Affiliation country:
Publication country:
NEW ZEALAND
/
NOVA ZELÂNDIA
/
NUEVA ZELANDA
/
NZ