Bacterial beta-ketoacyl-acyl carrier protein synthase III (FabH): an attractive target for the design of new broad-spectrum antimicrobial agents.
Mini Rev Med Chem
; 8(1): 36-45, 2008 Jan.
Article
in En
| MEDLINE
| ID: mdl-18220983
ABSTRACT
The emergence of drug resistant strains of important human pathogens has made urgent the necessity of finding new targets and novel antimicrobial agents. One of the most promising targets is FabH. In this review we summarize the progress made in the design of FabH inhibitors and the role played by the 3D-structure of the enzyme in the drug design process.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase
/
Bacteria
/
Drug Design
/
Anti-Infective Agents
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Mini Rev Med Chem
Journal subject:
QUIMICA
Year:
2008
Document type:
Article
Affiliation country: