Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury.
Biol Pharm Bull
; 31(2): 309-11, 2008 Feb.
Article
in En
| MEDLINE
| ID: mdl-18239293
ABSTRACT
Vitamin B(12) contains a cobalt complex and accumulates at high levels in the liver. Vitamin B(12) was examined for its hepatoprotective effect on dimethylnitrosamine-induced liver injury in mice. Vitamin B(12) decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the liver showed that the gene expression of alpha-smooth muscle actin and heat-shock protein 47, which are markers of fibrosis, were suppressed by vitamin B(12) administration. Our findings indicate that vitamin B(12) could be an effective hepatoprotective agent.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin B 12
/
Vitamins
/
Dimethylnitrosamine
/
Alkylating Agents
/
Chemical and Drug Induced Liver Injury
Limits:
Animals
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
2008
Document type:
Article
Affiliation country: