Treatment of intracerebral glioblastomas with G422 tumour cell vaccine in a mouse model.
J Int Med Res
; 36(2): 308-13, 2008.
Article
in En
| MEDLINE
| ID: mdl-18380941
ABSTRACT
The aim of this study was to develop a tumour vaccine with the ability to induce and expand higher affinity cytotoxic T lymphocytes and stimulate an effective antitumour immune response. The hypothesis tested was that G422 glioblastoma cells modified with B7-1 and interferon (IFN)-gamma genes could serve as a tumour vaccine. It was found that therapeutic subcutaneous immunizations with this tumour vaccine significantly induced a cytotoxic T-cell response and prolonged the survival of female Kuming mice with intracerebral G422 tumour isografts. The data collectively suggested that G422 glioblastoma cells genetically modified with B7-1 and IFN-gamma genes could serve as a tumour vaccine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Immunotherapy, Adoptive
/
Glioblastoma
/
Cancer Vaccines
/
Disease Models, Animal
Limits:
Animals
Language:
En
Journal:
J Int Med Res
Year:
2008
Document type:
Article
Affiliation country: