[Importance of the formulation for a chronopharmacologically optimised way of pain therapy. Results of a comparative bioavailability study of tramadol extended-release capsules after single-dose evening versus morning administration]. / Bedeutung der Galenik in der "chrono- adjustierten" Schmerzbehandlung. Ergebnisse einervergleichenden Bioverfügbarkeitsuntersuchung mit einem Tramadol- Retardpräparat nach Einmalgabe am Abend und am Morgen.
MMW Fortschr Med
; 150 Suppl 1: 36-42, 2008 Apr 10.
Article
in De
| MEDLINE
| ID: mdl-18540331
ABSTRACT
UNLABELLED Objective of this study was to investigate the rate and extent of tramadol bioavailability following evening versus morning administration. METHODS:
The study was performed following an open, randomised, cross-over study-design. 18 male and female volunteers were enrolled into the study and treated with 200 mg tramadol extended-release capsules (T-long), which were to be taken either in the morning or in the evening.RESULTS:
Plasma concentration versus time profiles obtained after morning and evening administration were almost superimposable for both, tramadol and its active metabolite. Maximum exposure of tramadol and O-desmethyltramadol (geometric means of c(max)-values) as well as extent of exposure (geometric means of AUC(0-48)-values) were comparable after morning and eveningadministration.CONCLUSIONS:
Time-point of administration does not have any relevant impact on the rate and extent of absorption in the investigated dosage form. Thus, time-point of administration may be adjusted to the patient's need in a chronopharmacologically optimised way for pain therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Tramadol
/
Analgesics, Opioid
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
De
Journal:
MMW Fortschr Med
Journal subject:
MEDICINA
Year:
2008
Document type:
Article