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HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
Fuchs, Dominik; Berges, Carsten; Opelz, Gerhard; Daniel, Volker; Naujokat, Cord.
Affiliation
  • Fuchs D; Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany.
Biochem Biophys Res Commun ; 374(2): 309-14, 2008 Sep 19.
Article in En | MEDLINE | ID: mdl-18625202

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyisoprenyl Phosphates / Burkitt Lymphoma / Apoptosis / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2008 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyisoprenyl Phosphates / Burkitt Lymphoma / Apoptosis / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2008 Document type: Article Affiliation country: