Facial wrinkles as a predictor of decreased renal function.
Nephrology (Carlton)
; 13(6): 522-7, 2008 Dec.
Article
in En
| MEDLINE
| ID: mdl-18771469
ABSTRACT
AIMS:
Oxidative stress generated either by exogenous or endogenous sources can lead to progressive organ damage and skin ageing over a long period of time. Moreover, some dermatological signs are independent of chronological ageing, and may reflect the long-term redox state of internal organs. Therefore, we hypothesized that there might be an association between facial wrinkles and decreased renal function, an oxidative stress-related disease.METHODS:
A cross-sectional study was carried out in a Korean population of 264 adults aged 30 years and older. Facial wrinkle scores in the crow's-foot area were estimated using a standardized form of visual assessment. As an index of renal function, we determined estimated glomerular filtration rate (eGFR). Lipid hydroperoxide (LPO) assay was performed to measure the levels of oxidative stress.RESULTS:
After adjusting for possible confounders, lower eGFRs and higher LPO levels were found in those with severe facial wrinkles.CONCLUSION:
We conclude that severe facial wrinkles might be used as a predictive marker of decreased renal function, independently of age, gender and other established risk factors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Aging
/
Glomerular Filtration Rate
Type of study:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Nephrology (Carlton)
Journal subject:
NEFROLOGIA
Year:
2008
Document type:
Article