Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.
Tetrahedron Lett
; 48(38): 6754-6758, 2007 Sep 17.
Article
in En
| MEDLINE
| ID: mdl-18797498
Sulfation of multiply hydroxylated small organic molecules is fraught with problems of poor yield, multitude of products and long reaction times. We have developed a rapid microwave-based method for synthesis of highly sulfated small organic molecules, which affords the per-sulfated product in moderate to excellent yields and high purity. The method is expected to be of value in the discovery of per-sulfated organic molecules as mimics of glycosaminoglycans, which are being increasingly recognized as modulators of key physiological functions.
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01-internacional
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MEDLINE
Language:
En
Journal:
Tetrahedron Lett
Year:
2007
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Article
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