CD8+ T suppressor cells and the ILT3 master switch.
Hum Immunol
; 69(11): 681-6, 2008 Nov.
Article
in En
| MEDLINE
| ID: mdl-18817834
ABSTRACT
Similar to helper and cytotoxic T cells, CD8(+) T suppressor cells (Ts) acquire antigen specificity via direct interaction with antigen-presenting cells (APC). They induce the upregulation of the inhibitory receptor immunoglobulin-like transcript (ILT)3 on professional and nonprofessional APC, rendering these cells tolerogenic and able to induce the differentiation of further waves of regulatory and suppressor T cells. This review sums up evidence that ILT3 is the centerpiece of CD8(+) Ts-driven suppression and acts as a master switch in the regulation of CD8(+) and CD4(+) T-cell responses to antigens in transplantation, autoimmunity, allergy, and cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Cell Surface
/
CD8-Positive T-Lymphocytes
Limits:
Humans
Language:
En
Journal:
Hum Immunol
Year:
2008
Document type:
Article
Affiliation country: