Effect of heme oxygenaseendogenous carbon monoxide on mortality during septic shock in rats.
Ir J Med Sci
; 178(4): 491-6, 2009 Dec.
Article
in En
| MEDLINE
| ID: mdl-19052841
ABSTRACT
AIM:
To investigate the effect of HOCO on mortality during septic shock in rats.METHOD:
Eighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ.RESULTS:
Death was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ (all P < 0.05). And CO and SOD activities were significantly higher in group SS than that in the group LZ (all P < 0.05). HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS (P < 0.05), whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups (all P > 0.05).CONCLUSION:
The increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shock, Septic
/
Carbon Monoxide
/
Heme Oxygenase-1
/
Heme Oxygenase (Decyclizing)
/
Hypotension
Limits:
Animals
Language:
En
Journal:
Ir J Med Sci
Year:
2009
Document type:
Article
Affiliation country: